No compelling evidence vaccination with Streptococcus pyogenes group A carbohydrate elicits cross-reactive rheumatic fever autoantibodies

• Parks_Cunningham_Saul_Submitted_06052025.pdf   Download
  (Preprint of submitted article, not yet peer-reviewed)

Full Value of Vaccine Assessment

• Group A Streptococcus: Full Value of Vaccine Assessment (FVVA) Report   Download

Strep A Vaccine Industry Forum: Catalyzing Industry Investment In Strep A Vaccine R&D

• SAVAC Industry Forum Report_2024.4.1.pdf   Download

SAVAC 2.0 immunoassay workshop in Abu Dhabi on 3Nov 2023

• SAVAC 2.0 workshop for immunoassay_3Nov2023.pdf   Download

List of publications from SAVAC 1.0

SAVAC Protocols in OFID

• All articles   Link
• Harmonizing Surveillance Methodologies for Group A Streptococcal Diseases   Link
• Standardization of Epidemiological Surveillance of Group A Streptococcal Pharyngitis   Link
• Standardization of Epidemiological Surveillance of Group A Streptococcal Impetigo   Link
• Standardization of Epidemiological Surveillance of Group A Streptococcal Cellulitis   Link
• Standardization of Epidemiological Surveillance of Invasive Group A Streptococcal Infections   Link
• Standardization of Epidemiological Surveillance of Acute Rheumatic Fever   Link
• Standardization of Epidemiological Surveillance of Rheumatic Heart Disease   Link
• Standardization of Epidemiological Surveillance of Acute Poststreptococcal Glomerulonephritis   Link

Data Purpose Matrix

• Moore SAVAC DPM CID2022.pdf   Download

SAVAC NPJ Vaccines health economics papers

• Modeling the potential health impact of prospective Strep A vaccines   Link
• The potential global cost-effectiveness of prospective Strep A vaccines and associated implementation efforts   Link
• Optimal global spending for group A Streptococcus vaccine research and development   Link
• Global economic burden per episode for multiple diseases caused by group A Streptococcus   Link
• A Strep A vaccine global demand and return on investment forecast to inform industry research and development prioritization   Link

NPJ Vaccine pipeline

• The Streptococcus pyogenes vaccine landscape   Link

Safety paper

• Safety of Streptococcus pyogenes Vaccines: Anticipating and Overcoming Challenges for Clinical Trials and Post-Marketing Monitoring   Link

Immune correlates paper

• Correlates of immunity to Group A Streptococcus: a pathway to vaccine development   Link

WHO expert review of Group A Streptococcus vaccines: Hybrid Consultation by IVIR-AC and PDVAC, London, UK, 30 September 2022

• who-expert-review-of-gas-vx-exec-summary-pdvac-and-ivirac-final.pdf   Download

SAVAC 2nd Stakeholders meeting Report 06JUNE2022

• SAVAC 2nd Stakeholders meeting Report 06JUNE2022.pdf   Download

Presentation slides at the second SAVAC Stakeholders Meeting, 06 June 2022

• 1. A strategic approach to understand strep A disease burden_Jonathan Carapetis.pdf   Download
• 2. Immunologic protection and correlates_Shiranee Sriskandan.pdf   Download
• 3. Strep A Vaccine Safety Considerations and Guidance during Development_Edwin Asturias.pdf   Download
• 4. Potential impact of prospective strep A vaccines on the global burden of disease_model based analysis_Kaja Abbas.pdf   Download
• 5. Global economic burden for Strep A infections and cost effectiveness analysis for a hypothetical Strep A vaccine_Jung Seok Lee.pdf   Download
• 6. The full health economic social benefits of vaccination_conceptual framework and application to Strep A vaccines_Dan Cadarette.pdf   Download
• 7. The Effect of a Prospective Vaccine Against Group A Streptococcus on Global Antibiotic Consumption for Sore Throat_Jeff Cannon.pdf   Download
• 8. Global health and economic benefits _Maddalena Ferranna.pdf   Download
• 9. Business Case for Industry Investment in Strep A Vaccine R&D_Don Walkinshaw.pdf   Download
• 10. Optimal Global Spending for Group A Streptococcus Vaccine Research and Development_Dan Tortorice.pdf   Download

SAVAC Stakeholders meeting Report 13JUNE2021

• SAVAC Stakeholders meeting Report 13JUNE2021.pdf   Download

SAVAC High Level Development Strategy 8MAY2020

• SAVAC High Level Development Strategy 8MAY2020.pdf   Download

Vekemans WHO GAS vaccine R&D roadmap CID 2019

• Vekemans WHO GAS vaccine R&D roadmap CID 2019.pdf   Download

WHO-IVB-18.07-WHO Preferred Product Characteristics for GAS Vaccines 2018

• WHO-IVB-18.07-WHO Preferred Product Characteristics for GAS Vaccines 2018.pdf   Download

WHO-IVB-18.08-GAS Vaccine Develoment Technology Roadmap 2018

• WHO-IVB-18.08-GAS Vaccine Develoment Technology Roadmap 2018.pdf   Download