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Early rheumatic heart disease is a recognized intermediate on the pathway to advanced rheumatic heart disease
SAVAC TAWG (Technical Advisory Working Group) meeting reports from SAVAC Forum in Brisbane on June 1, 2025.
Models of Vaccine Finance and Their Potential Application to Group A Streptococcus Vaccines
No compelling evidence vaccination with Streptococcus pyogenes group A carbohydrate elicits cross-reactive rheumatic fever autoantibodies
Full Value of Vaccine Assessment
  • Group A Streptococcus: Full Value of Vaccine Assessment (FVVA) Report   Download
Strep A Vaccine Industry Forum: Catalyzing Industry Investment In Strep A Vaccine R&D
  • SAVAC Industry Forum Report_2024.4.1.pdf   Download
SAVAC 2.0 immunoassay workshop in Abu Dhabi on 3Nov 2023
  • SAVAC 2.0 workshop for immunoassay_3Nov2023.pdf   Download
List of publications from SAVAC 1.0

SAVAC Protocols in OFID
  • All articles   Link
  • Harmonizing Surveillance Methodologies for Group A Streptococcal Diseases   Link
  • Standardization of Epidemiological Surveillance of Group A Streptococcal Pharyngitis   Link
  • Standardization of Epidemiological Surveillance of Group A Streptococcal Impetigo   Link
  • Standardization of Epidemiological Surveillance of Group A Streptococcal Cellulitis   Link
  • Standardization of Epidemiological Surveillance of Invasive Group A Streptococcal Infections   Link
  • Standardization of Epidemiological Surveillance of Acute Rheumatic Fever   Link
  • Standardization of Epidemiological Surveillance of Rheumatic Heart Disease   Link
  • Standardization of Epidemiological Surveillance of Acute Poststreptococcal Glomerulonephritis   Link

Data Purpose Matrix
  • Moore SAVAC DPM CID2022.pdf   Download

SAVAC NPJ Vaccines health economics papers
  • Modeling the potential health impact of prospective Strep A vaccines   Link
  • The potential global cost-effectiveness of prospective Strep A vaccines and associated implementation efforts   Link
  • Optimal global spending for group A Streptococcus vaccine research and development   Link
  • Global economic burden per episode for multiple diseases caused by group A Streptococcus   Link
  • A Strep A vaccine global demand and return on investment forecast to inform industry research and development prioritization   Link

NPJ Vaccine pipeline
  • The Streptococcus pyogenes vaccine landscape   Link

Safety paper
  • Safety of Streptococcus pyogenes Vaccines: Anticipating and Overcoming Challenges for Clinical Trials and Post-Marketing Monitoring   Link

Immune correlates paper
  • Correlates of immunity to Group A Streptococcus: a pathway to vaccine development   Link
WHO expert review of Group A Streptococcus vaccines: Hybrid Consultation by IVIR-AC and PDVAC, London, UK, 30 September 2022
  • who-expert-review-of-gas-vx-exec-summary-pdvac-and-ivirac-final.pdf   Download
SAVAC 2nd Stakeholders meeting Report 06JUNE2022
  • SAVAC 2nd Stakeholders meeting Report 06JUNE2022.pdf   Download
Presentation slides at the second SAVAC Stakeholders Meeting, 06 June 2022
  • 1. A strategic approach to understand strep A disease burden_Jonathan Carapetis.pdf   Download
  • 2. Immunologic protection and correlates_Shiranee Sriskandan.pdf   Download
  • 3. Strep A Vaccine Safety Considerations and Guidance during Development_Edwin Asturias.pdf   Download
  • 4. Potential impact of prospective strep A vaccines on the global burden of disease_model based analysis_Kaja Abbas.pdf   Download
  • 5. Global economic burden for Strep A infections and cost effectiveness analysis for a hypothetical Strep A vaccine_Jung Seok Lee.pdf   Download
  • 6. The full health economic social benefits of vaccination_conceptual framework and application to Strep A vaccines_Dan Cadarette.pdf   Download
  • 7. The Effect of a Prospective Vaccine Against Group A Streptococcus on Global Antibiotic Consumption for Sore Throat_Jeff Cannon.pdf   Download
  • 8. Global health and economic benefits _Maddalena Ferranna.pdf   Download
  • 9. Business Case for Industry Investment in Strep A Vaccine R&D_Don Walkinshaw.pdf   Download
  • 10. Optimal Global Spending for Group A Streptococcus Vaccine Research and Development_Dan Tortorice.pdf   Download
SAVAC Stakeholders meeting Report 13JUNE2021
  • SAVAC Stakeholders meeting Report 13JUNE2021.pdf   Download
SAVAC High Level Development Strategy 8MAY2020
  • SAVAC High Level Development Strategy 8MAY2020.pdf   Download
Vekemans WHO GAS vaccine R&D roadmap CID 2019
  • Vekemans WHO GAS vaccine R&D roadmap CID 2019.pdf   Download
WHO-IVB-18.07-WHO Preferred Product Characteristics for GAS Vaccines 2018
  • WHO-IVB-18.07-WHO Preferred Product Characteristics for GAS Vaccines 2018.pdf   Download
WHO-IVB-18.08-GAS Vaccine Develoment Technology Roadmap 2018
  • WHO-IVB-18.08-GAS Vaccine Develoment Technology Roadmap 2018.pdf   Download